Warm Materials in PI3K/Ark/mTOR inhibitor Library



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LY294002 may be the initially artificial molecule proven to hinder PI3Kα/δ/β with IC50 of .5 μM/.57 μM/.97 μM in mobile phone-free of charge assays, respectively much more stable in solution than Wortmannin, and also disables autophagosome formation.



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Perifosine (KRX-0401) is a unique Akt inhibitor with IC50 of 4.7 μM in MM.1S cellular material, concentrates on pleckstrin homology website of Akt. Stage 3.



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Everolimus (RAD001) is undoubtedly an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM within a mobile-free assay.

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