[“Dopamine Agonist

The two models, retinal and focal cerebralischemia, differ not onlywith respect to methodological aspects and time course of development of the lesions, but probably as important, they differwith respect to cellular composition in the regions a ffected by theischemic insult.In the retinalischemia model, we have obtained ev idence that the di stinct neuronal cell populations present in the various retinal layers differwith respect to sensitivityto theischemic insult and expression of. Therefore, the opposite role of TN FR determined in the two models, di sease promoting in the case of retinalischemia, may reect thisdifferent cellular composition in the targeted areas and a differential cellular response to TN F exposition.However, veryrecent data obtained in an experimental autoimmune encephalomyelitismodel also suggest an antagoni stic action of the two TN F receptors, whichis infull accordancewith our data obtained in retinalischemia and strengthen our hypothesisof a differential role of the two TN F receptors in vivo.Nature. The user has requested enhancement of the downloaded file.Therefo re, an ideal compound would have two characteristics: neuroprotective action and an antiaging effect.The natural compound resveratrol is a suitable candidate for this purpose due to its low toxicity and antioxidant properties.In addition, we discu ss the possibility of using resveratrol in the treatmentof neurodegenerativediseases.In the con textof neurodegenerativediseases the main problem is that no effective treatments currently ex ist.One proposed strategy for the treatmentof neurodegenerative disorders that has gained considerab le atten tion is the useof natural antiox idant agents. The main advan tage of all these agents, which are main ly natural compounds, is their safety. One clin ical study suggested that in patients with moderately severe AD the administration of vitamin E led to a slight delay of disease progression, thus providing evidence for the beneficial effects of this vitamin as partof an AD treatment. In keeping with these results, other studies with vitamin C, caroteno ids and other antiox idants in AD patients have argued that these antiox idants might also have a protective effect against th is disease. Thus, antioxidant drugs could have a potential application in neuropharmacology, although any drug that is shown to have add itional, beneficial pharmaco logical effects above and beyond its an tioxidant proper ties would beof even greater in terest.In this context, attention has turned to resveratrol, a naturallyoccurring polyphenolic compound with strong antioxidantproperties and which is abundantly found as a component of redwine. Oxidative stress is known to induce intracellular cell damage that affects all the biological componen ts such as DNA, lip ids, sugars and proteins. Therefore, the imbalance between in Benzocaine tracellu lar ROS and antioxidantdefence mechanisms results in oxidative stress that is harmful for neurons.Neurons may thus show a reduced capacity to compensate for this imbalance, and since age is also Curcumin related with a similar reduction in this capacity, this can lead to irreversible injury and, as such, contr ibute to the pathogenesis of neurodegenerative diseases.The first mechanism to be described as regards the pharmacological properties of RESV was its antiox idant effects. Although interest in th is compound was in itially focused on its antioxidantproperties it has since been reported to possess a wide range of biolog ical and pharmacological activ ities includ ing anti inflammatory, an timutagenic, and anticarcinogen ic effects.

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