Agonist Antagonist

However, lncRNA studies are still in their infancy and the functions of the vast majority of lncRNA transcripts remain unknown.It is generally known that the function of the human nervous system largely relies on the precise regulation of gene expression.Since then, with the improvement of Flurbiprofen microarray Curcumin sensitivity and sequencing technology, various novel lncRNA transcripts have been found. Therefore, having a comprehensive review of these existing lncRNA classifications are of great importance.The ENCODE consortium provided detailed profile of three subnuclear compartments to reveal their lncRNA compositions. Recently, the heated debate on how many human genes are functional has been raised by scholars worldwide, putting forward the idea that more than of the human genome is functional. The main pathological change associated with AD is the aggregation of amyloid plaques on neurons that are derived from the proteolytic processing of the amyloid precursor protein. BACEAS has been shown to be capable of upregulating BACE mRNA by forming a stabilizing duplex with the mRNA that results in an increase in BACE protein levels. This finding may be important in the development of therapies for AD.BCYRN plays an important role in modulating local protein synthesis in dendrites, and overexpression of BCYRN in AD and aging brains could be a cause of synaptodendritic deterioration.One possible explanation for the differences may stem from variances in the sampling location of the brain or in the severity of disease.GDNFAS is transcribed from the opposite strand of GDNF gene whose expression levels are impaired in neurodegenerative diseases and is only found in primate genomes. Inflammation in AD brains can trigger A expression, thereby enhancing the secretion of amyloid is a stable transcript in mouse embryonic stem cells associated with embryo differentiation. Their results do not support previous findings, suggesting that further studies using largescale association analyses are required. The gene BDNF encodes a secreted growth factor that promotes neuronal maturation and survival.The overlapping antisense lncRNA, BDNFAS, has been shown to inhibit BDNF expression posttranscriptionally. Patients with HD have reduced levels of BDNF in the brain, and it has been shown that overexpression of BDNF in the forebrain rescues HD phenotypes in a mouse model. Given that BDNF plays such a key role in HD, downregulating BDNFAS and thereby increasing BDNF levels could be a plausible approach for HD therapy. Johnsons group investigated lncRNA expression in human HD brain tissues and found that the expression of HAR was significantly decreased in the striatum, due to the activation of specific DNA regulatory motifs resulting in transcriptional repression. Additionally, huntingtin antisense is downregulated in the human HD frontal cortex; however, its function remains unknown.NEAT, which is one of the first examples of a transcript necessary for the formation of paraspeckles, may play specific roles in the pathology of the brain as its expression is upregulated in the nucleus of heroin users.Although no functional studies have been carried out with DGCR, this neuralspecific, diseaseassociated transcript may have an important function within the human nervous system.MEG is transcribed into a wide variety of splice isoforms and is found on human chromosome.

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