Agonist Chemicals

Various compounds, specically antioxidants, counteract the eect of oxidative stress and reduce the risk of dreadful diseases. This class of antioxidants draws attention because of having good ecacy in terms of the prevention and treatment of diseases, without any side eects. Though mitochondria are a hub of oxygen and ROS, there exists a homeostatic control in the cell to check the level of ROS under normal conditions.Neurodegenerative diseases are specically characterized by apoptosisnecrosis and dysfunction of neuronal cells, leading to a malign eect on the neural system.Being the extensively active part of body, the brain is more vulnerable to oxidative stress.The brain has a higher demand for oxygen and thus consumes more oxygen than other parts of body.The brain is also enriched in redoxactive metals that actively participate in ROS generation.As the brain cell membranes are rich in PUFA, they are more prone to lipid peroxidation. Although, when present in the optimum concentration, the antioxidant glutathione plays a major role in detoxication of ROS species in brain cells.Usually, AD is called a disease of ageing, but in some cases, it is also observed in the young population.Alzheimer s disease is manifested with the deposition of protein aggregates, extracellular amyloid plaques or neurobrillary tangles, and loss of synaptic connections in specic regions of brain. The neuropathological diagnostic feature of AD is the accumulation of neurotoxic A oligomer peptides, which, along with protein, mediates neurodegeneration, thus causing neuroinammation, impairment in synaptic connection, cholinergic denervation, neurotransmitter imbalance, neuronal loss, dendritic alterations, and so on.Massive reports suggest a signicant role of ROS and oxidative stress in AD via having a Benzyl alcohol deleterious eect on biomoleculesspecically, proteins. It is evidenced that the oxidative imbalance that leads to the neuronal damage may play a central role in AD.Accumulation of A aggregates is also found to play a pivotal role in OS, which leads to mitochondrial dysfunction and energy failure.Metals such as iron, zinc, copper, and so on, which also act as an antioxidant, accumulate in brain as ageing occurs.Various enzymes also require metals for their proper functioning, which is found to be hampered in the AD brain.The role of beta amyloid is still illusive, but it is illustrated to act as an antioxidant, causing hindrance in the formation of hydroxyl radical and thus leading to the prevention of protein and lipid oxidation in mitochondria of rats. Beta amyloid interacts and binds with redox active metals like copper, zinc, and iron, and in this manner, is involved in signaling control of cellular physiology.Beta amyloid undergoes aggregation via complexing with copper in its redox state. Similarly, zinc and iron were found to be involved in microtubule and tau pathology, and it was found that these can bind tau and aggravate aggregation and phosphorylation. Surprisingly, the high concentration of zinc was demonstrated to be interlinked with 5-hydroxytryptophan memory and cognitive regions of the brainspecically the amygdala, neocortex, and hippocampus are found to be signicantly aected in AD patients. The highly ordered state of A fragment, that is, A, binds to the zinc and promotes the generation of toxic, brillary A aggregates.

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